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Demand for these weight-loss drugs is also high as Indias population of more than 1.4 billion faces a higher burden of diabetes and cardiovascular ailments, largely due to increasingly sedentary urban lifestyles

Novo Nordisk does have an FDA-approved oral GLP-1 drug, Rybelsus, but its impact on weight loss has been moderate

TMAO alters how cholesterol is metabolized so less is eliminated from the body, allowing more cholesterol to deposit and harden into the artery walls (atherosclerosis)

Several studies indicate that histamine also exerts H-3-mediated anti-diabetic properties (144146) (Table 1)

Milestones in the journey towards addressing obesity