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Protocols are typically structured around consistent use over a defined period to allow the body to fully respond to the therapy

2 There is insufficient data to recommend other formulations of vitamin B 12 replacement (e.g., nasal, sublingual, subcutaneous)

The recommended daily intake of vitamin B12 varies depending on age, sex, and life stage

(e) Assignment of Geographic Areas to Clinicians We proposed at 512.710(b)(4) that, to meet the ASM participant eligibility criteria, clinicians must be located in one of the selected mandatory geographic areas