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Nausea, constipation, and reflux are common, especially during dose escalation, and going slower or staying lower feels like the obvious fix

Its part of what makes the preparation legally distinct from the approved product

Eur J Obstet Gynecol Reprod Biol 171(1):8487

Current advancements in this field have centered on improving selectivity to reduce on-target effects, which ultimately increases safety profiles [19]