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New England Journal of Medicine 2023 03 Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial Rosenstock J, Frias J, Jastreboff AM, et al

Rizzo JF III

Tirzepatide also has a significantly longer half-life of approximately 5 days, which allows for once-weekly dosing

In practice with GHK-Cu: The copper dose delivered via typical topical or therapeutic administration is modest Short-term use has not been prominently associated with clinically significant zinc depletion Long-term or high-dose use warrants monitoring in patients where zinc balance is clinically important Patients with known zinc deficiency or on zinc-replacement should be monitored more closely A reasonable clinical approach: monitor copper and zinc status in patients on chronic GHK-Cu, particularly in symptomatic or long-duration protocols

doi: 10.7861/clinmedicine.15-2-145 Pubmed Abstract CrossRef Google Scholar View reference in article 75 BrasitusTA