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The first molecules that were developed were based on an exendin-4 backbone which was isolated from the saliva of the Gila monster ( Heloderma suspectum ) which shares 53% homology with GLP-1
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Sambamurti et al., 2002
Large-scale population studies show 50% lower rates of alcohol binging and 40% reduced opioid overdose risk among GLP-1 users ^16
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