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RxList (WebMD)

Managing Your Tirzepatide Injection Schedule and Side Effects Common side effects during tirzepatide dose escalation include mild nausea, decreased appetite, and occasional constipation, which typically resolve within 23 weeks as your body adapts

L., Teruel-Puche, J

Importantly, unlike traditional antidiabetic therapies that can cause weight gain, GLP1 RAs often result in modest to substantial weight loss, depending on dose and individual response

In addition, since glutamate taken back up into neurons may be available for re-use as a neurotransmitter, reduced reuptake might also lead to a requirement for enhanced synthesis, and consequently to an increase in whole-tissue glutamate