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se manejan como compuestos de investigacin

A very clear clinical framing of peptides

Proc (Baylor Univ

sitagliptin Sitagliptin Trade Name: Januvia Drug Class: oral hypoglycemics Mechanism of Action: An inhibitor of dipeptidyl peptidase-4 (DPP-4), a protease that degrades the incretin GLP-1 Incretins are hormones released from the GI tract in response to nutrient ingestion Incretins potentiate glucose-stimulated insulin secretion from beta cells in the pancreas As a result of inhibiting DPP-4, increased or prolonged GLP-1 levels are able to potentiate the secretion of insulin by the pancreas The effect produced by DPP-4 inhibitors is dependent on endogenous GLP-1 levels, and produce a modest effect on GLP-1 activity compared to giving GLP-1 receptor agonists (hence DPP-4 inhibitors do not have the same impact to produce weight loss as GLP-1 agonists)

The OASIS 4 trial shows that oral semaglutide 25 mg delivers meaningful weight loss (13.6%) in people with overweight or obesity narrowing the gap with both the 50 mg oral dose and the 2.4 mg injectable formulation, while offering patients a daily pill option instead of a weekly injection Oral_Semaglutiude