1034,1807,1808 An increase in thyroid C-cell hyperplasia, adenomas, and medullary thyroid carcinomas was observed in preclinical rodent studies of liraglutide, while exenatide has been shown to cause nodular C-cell lesions without medullary thyroid carcinoma, 1809,1810 leading to concerns regarding the potential for development of medullary thyroid carcinoma in persons with DM on GLP-1 RAs
Prozac, while not a stimulant can be associated with symptoms associated with stimulation such as anxiety
For example, liraglutide (LEADER trial), injectable semaglutide (SUSTAIN-6), dulaglutide (REWIND), and high-dose semaglutide (SELECT) have shown cardiovascular risk reduction in their respective clinical trials
But that doesnt mean semaglutide is perfectly safe
One exciting and developing finding is that GLP-1s can improve fertility in certain women, particularly those struggling with overweight or obesity, or who have polycystic ovary syndrome (PCOS)