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Description

Adding GIP receptor (GIPR) agonism introduces a second incretin pathway that enhances insulin secretion through distinct cAMP signaling, independently modulates adipocyte lipid handling, and engages central appetite circuits through complementary routes to GLP-1R

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N Engl J Med 2020;383:2219e29

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The drug has been approved globally for the management of type 2 diabetes mellitus in adult patients in the U.S

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