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Gerard L, Lecocq M, Detry B, Bouzin C, Hoton D, Pinto Pereira J, et al

b , Cytokine levels in murine tissue homogenate of lungs infected with the WT (red) or gsh2 mutant (blue) strains at the indicated timepoints ( n = 8 lungs for each strain at each time point)

Prolonged exposure to supraphysiological doses of exogenous testosterone or synthetic anabolicandrogenic steroids (AAS) is associated with marked suppression of the hypothalamicpituitarygonadal (HPG) axis through negative feedback mechanisms that inhibit gonadotropin secretion (76)

In clinical trials of SGLT2 inhibitors in type 2 diabetes, discontinuation rates among those receiving active treatment have been less variable, ranging from 21% during a median follow-up time of 50 months in the DECLARE-TIMI 58 trial of dapagliflozin to 29% during a mean follow-up time of 43 months in the CANVAS trial of canagliflozin [14,15,16,17,18]

Med 16 , 462468 (2015)