Discussion The results of this study show that either the acute- or short-term administration of the peripheral DBH inhibitor, etamicastat, decreases blood pressure in both non-anesthetized and anesthetized mice with germ line deletion of Drd2 or renal-selective silencing of Drd2 (renal subcapsular infusion of Drd2 siRNA in D 2 +/+ mice) but not in wild-type littermates or D 2 +/+ mice that received renal subcapsular infusion of non-silencing siRNA
Jimenez RV, Kuznetsova V, Connelly AN, Hel Z, Szalai AJ
Boronic acid-functionalized core-shell-shell magnetic composite microspheres for the selective enrichment of glycoprotein
The blend wins on three axes: it consolidates one reconstitution event instead of three (which reduces the probability of an aseptic technique error somewhere in the chain), it locks the three peptides into one ratio so that a single 0.20 mL draw delivers a fixed combination, and it consumes one storage slot in the fridge instead of three
[DOI] [PMC free article] [PubMed] [Google Scholar] 158
