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Metabolic-bariatric surgery is strongly supported by AASLD and American Society for Metabolic and Bariatric Surgery guidelines 20,29 for patients with MASH and obesity, with sleeve gastrectomy and Roux-en-Y gastric bypass demonstrating MASH resolution rates of 55% to 80% and meaningful fibrosis regression

Metabolic adaptation occurs in some individuals, where the body adjusts to reduced caloric intake by decreasing metabolic rate

Semaglutide may be appropriate for adults who have struggled to lose weight through diet and activity changes

How Dihexa Works (Proposed and Partly Retracted) The proposed mechanism is that Dihexa potentiates hepatocyte growth factor (HGF) signaling at the c-Met (MET) receptor, downstream of PI3K-AKT, driving dendritic spine formation and synaptogenesis

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