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95% CI, 0.62-0.72

In contrast to these rodent studies, only a very few studies are available that assessed effects in humans

Effects of nitric oxide on the contraction of skeletal muscle

206,220,221 Given that endoplasmic reticulum stress, impaired autophagy and proliferation, and increased apoptosis are all suggested to promote islet beta-cell pathology in T2D, and the findings that GLP-1R activation can influence all of these give GLP-1 and its analogues a role beyond just enhancing insulin secretion

1 Drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, toxic epidermal necrolysis and other severe adverse reactions are fortunately less common