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Commonly reported observations include: Reduced joint stiffness, particularly morning stiffness Improved range of motion in affected joints Decreased reliance on anti-inflammatory medications Better tolerance of physical activity and exercise These clinical observations are valuable but represent anecdotal evidence

As shown in Figure 7 , AQ-QI and DEAQ-QI exposure resulted in activation of the ER stress response

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Notably, their effects extend beyond simple antioxidant activity, through multi-targeted mechanisms, they offer therapeutic approaches for intervening in the E-P-OS network