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10.1016/j.mad.2014.01.002 301

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Advances in structural biology and predictive modelling of flavoprotein-cofactor interactions promise to refine genetic diagnostics and pave the way for genotype-guided, riboflavin-based precision therapies

(2) DADA2 denoising: Data was processed using dada2 ( Identification (amplicon sequence variants (ASVs)), diversity analysis, differential analysis, correlation analysis and functional prediction The qualified sequences with more than 97% similarity thresholds were allocated using dada2 to generate ASVs, and the samples with ASV counts less than 2 were filtered (Quast et al., 2013) with a confidence threshold of 70%