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Anthony Didato, DMD Balanced Aesthetics + Wellness Leaky Gut (Intestinal Permeability) and Systemic Inflammation Increased intestinal permeability allows endotoxins (LPS) to enter the bloodstream, triggering systemic inflammatory cascades linked to anxiety, depression, brain fog, Frontiers in Immunology KPV Anti-Inflammatory Tripeptide From Alpha-MSH KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (alpha-MSH) with potent anti-inflammatory properties

doi: 10.1159/000348250

The mechanism isn't fully mapped, but it likely involves circadian modulation of vagal afferent sensitivity

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Hydration: Blood flow and nutrient transport to healing tissue depend on it