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Schedule an appointment if you experience: Sudden or significant decrease in sexual desire that affects your quality of life or relationships New-onset erectile dysfunction or difficulty with arousal Painful intercourse or other physical symptoms during sexual activity Concerning changes in sexual function accompanied by other symptoms such as mood changes, fatigue, or hormonal symptoms New or worsening depression or suicidal thoughts (Zepbound carries a warning for suicidal ideation) Severe, persistent abdominal pain (with or without vomiting), which could indicate pancreatitis or gallbladder disease requiring urgent evaluation Your physician can conduct a thorough assessment to identify potential underlying causes

Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice

But standard physical function measures like chair rise and gait speed did not change or improved slightly with semaglutide

Disclaimer: This is not a large study and does not include many patients

While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control