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Since single F pathway could produce higher amounts of GSH compared with other pathways, we tried to augment the copies of F pathway by further integration of gshF to improve the productive capacity of GSH of engineered strain W303-1b/F

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Liraglutide, semaglutide and tirzepatide are incretin-based therapies currently approved by FDA for the management of obesity, while triple GIPR/GCGR/GLP-1R agonist retatrutide (LY3437943), the cagrilintide/semaglutide (CagriSema) 2.4 mg combination, high-dose oral semaglutide, and oral orforglipron are in advanced stages of development

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