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According to literature, Asn240 is involved in the stabilization of a conserved water molecule, which is required for the deprotonation of monophenolic substrates

By correctly phenotyping irAEs and understanding the varied presentations and natural history, we can begin to develop a framework to distinguish between AEs associated with conventional chemotherapy or targeted therapy and immunotherapy

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[1] [2] This combined approach results in improved glycemic control, significant weight reduction, and improvements in certain cardiovascular risk factors such as blood pressure and lipid profiles