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The presence of Ala88 in VP1 of wt PV2 compared with Tyr75 at this position in the CVB3-CP17 structure avoids a steric clash that would otherwise disrupt the orientation of the compound in the wt PV2-CP17 complex (Fig

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They are typically sold as lyophilized powder requiring reconstitution and lack the quality assurance infrastructure of regulated pharmacies

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SC-Ad6-1 was shown to produce 100-fold more spike protein and provided better protection in hamsters than a replication-defective Ad [173]