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Efficacy and safety of cagrilintide with semaglutide in type 2 diabetes

These medicines include tricyclic anti-depressants (amitriptyline), serotonin-noradrenaline reuptake inhibitors (duloxetine and venlafaxine), and selective serotonin reuptake inhibitors (fluoxetine and paroxetine)

[DOI] [PubMed] [Google Scholar] 166.Burhanolu T., Halbutoullar Z.S., Turhal G., Demiroglu-Zergeroglu A

In Phase 2 trials published in the *New England Journal of Medicine* (2023), participants lost an average of 17.5% of body weight at the highest dose over 24 weeks outperforming tirzepatide and semaglutide in head-to-head data comparisons

4-HNE represents a highly reactive lipid peroxidation byproduct that induces cellular damage by interacting with proteins, DNA, and other cellular components through iron- and oxygen-mediated chain-breaking reactions (7)