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Macrodosing is typically for individuals who need more aggressive support to improve blood sugar regulation or achieve large-scale weight reduction

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For most GLP-1 receptor agonists, the answer depends on your specific medication and personal routine

Xultophy, another Novo Nordisk product, combines insulin degludec (the active ingredient in Tresiba) with liraglutide (a GLP-1 receptor agonist) in a single injection

A 2026 systematic review of 37 studies found that discontinuing treatment was associated with weight regain of roughly half a pound per month, with researchers projecting a return to baseline weight within about 1.5 years