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Moreover, research has shown that there are genetic links between type 2 diabetes and psychiatric disorders

While not absolutely contraindicated, active intestinal inflammation combined with GLP-1's effects on motility may trigger flares or worsen existing symptoms

Additional secondary endpoints include evaluation of maintenance of at least 15% body weight reduction from SURMOUNT-5 baseline for participants who had already lost at least 15% body weight reduction after 72 weeks of tirzepatide or semaglutide treatment, change (in kg) and percent change in body weight from baseline to week 52, and change in waist circumference (in cm) from baseline to week 52

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