Interestingly, BCRP is expressed at significantly higher levels than Pgp in the human BBB, whereas the opposite is observed in the rodent BBB (175)
Healthcare professionals should encourage patients taking Wegovy to maintain a varied, nutrient-dense diet and consider referral to a registered dietitian for personalised nutritional counselling, particularly for those with pre-existing deficiencies or at higher risk of malnutrition
In the COMBINE 2 trial in individuals with T2D inadequately controlled with GLP-1RA, with or without additional oral glucose-lowering medications, IcoSema as compared to semaglutide 1.0 mg provided superiority in HbA 1c reduction from baseline to week 52 and greater improvement in fasting plasma glucose with comparable rate of combined clinically significant or severe hypoglycemia, while the weight change was in favor of semaglutide 1.0 mg [14]
Clinicians often assemble an incretin mimetics drug list that includes both marketed injectables and oral semaglutide, with future additions expected as trials read out and approvals evolve
Each possesses a formidable reputation, backed by a growing body of preclinical data suggesting significant potential
