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multiple agent therapy including but not limited to wherein each agent is independently a sub-therapeutic dose, with either sequential or concurrent administration of the agents, will produce the desired pharmacological response, such as an erection sufficient for sexual intercourse, in patients with nerve damage, such as resulting from a prostatectomy or spinal cord injury, who are marginally responsive to a PDE-5 inhibitor such as sildenafil

Indeed, vitamin therapy (folic acid, pyridoxine plus cyanocobalamin) reportedly retards the progression of carotid plaques in patients with plasma homocysteine above and below 14 mol/L (Hackam et al, 2000)

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