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Under these circumstances, Nrf2 migrates to the nucleus and activates genes driven by the antioxidant response element (ARE), thereby promoting redox homeostasis

Free Radic Biol Med 126:87100 Yang Y, Zhou X, Xu M et al (2017) -lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers

The time frame for collagen remodeling is measured in months, not days

Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression

GA, through the activation of the ERK signaling pathway, enhances Nrf2-mediated antioxidant responses, safeguarding liver cells and mitigating hepatotoxicity induced by t-BHP (Rasool et al., 2010)