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Mechanistically, BPC-157 appears to modulate the nitric oxide (NO) pathway, interact with growth hormone receptors, and influence several molecular pathways involved in angiogenesis, fibroblast migration, and collagen deposition

The active form of B6, pyridoxal 5-phosphate (PLP), is required by the enzyme aromatic L-amino acid decarboxylase (AADC), which catalyzes the final step in producing both serotonin from tryptophan and dopamine from L-DOPA

The newer agents are more effective and have and convenient weekly dosing but they remain under patent protection, expensive, and increasingly out of reach for many patients and health plans

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So instead of suppressing it, we removed the signals demanding its production