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In the STEP 1 trial, once-weekly 2.4mg semaglutide produced a mean 14.9% body-weight reduction over 68 weeks establishing GLP-1 agonism as a leading anti-obesity mechanism

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After filtering on samples passing SomaLogic quality control (RowCheck = =TRUE) and selecting aptamers targeting human proteins, the remaining data covering 7,289 aptamers were log 10 transformed and, for each aptamer, all measurements standardized using the mean and standard deviation (s.d.) of samples obtained at baseline