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In addition, the important role of enzymes that can metabolize xenobiotics and produce metabolites that may also be toxic to the fetus should be noted

So CagriSema applies two independent signals that both converge on decelerating the stomach: cagrilintide via amylin/AMY receptors in the area postrema and its vagal output, and semaglutide via GLP-1 receptors on vagal afferents and in the brainstem

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