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Clinical experiments using nicotinamide (NAM), a derivative of vitamin B3, provided evidence in favor of the hypothesis that vitamin B3 mediates efficient chemoprevention against non-melanoma skin cancer (81)

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Clinical trials across various autoimmune diseases, such as SLE, RA, type 1 diabetes, and Primary Sjgren's Syndrome, have demonstrated that Low-dose IL-2 can safely and effectively induce stable Treg cell proliferation and restore immune balance, leading to improved disease activity (266271)

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