Side Effects Common side effects Nausea Vomiting Diarrhea Stomach pain Loss of appetite Serious but less common side effects Risk of pancreatitis Gallbladder issues (gallstones, inflammation) Kidney problems (from dehydration due to vomiting/diarrhea) Potential increased risk of thyroid C-cell tumors (based on animal studies) Patients should report severe or unusual symptoms to their healthcare provider immediately
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Current NHS eligibility criteria for semaglutide 2.4 mg (Wegovy) for weight management, according to NICE TA875, include: Body Mass Index (BMI) 35 kg/m with at least one weight-related comorbidity (such as type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea) For people from certain high-risk ethnic groups (such as South Asian, Chinese, Black African, or African-Caribbean), lower BMI thresholds apply (typically reduced by 2.5 kg/m) Treatment must be prescribed within specialist weight management services only Treatment is limited to a maximum duration of 2 years Must be used as an adjunct to a reduced-calorie diet and increased physical activity Liraglutide 3 mg (Saxenda) availability varies significantly across NHS regions and is not routinely commissioned in many areas
[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Ast J., et al