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Clinical trials show that heart rate increases typically occur early in treatment, peak around the 6-month mark, and then decline and stabilize as your body adjusts

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The following sections examine representative systemsapelin, spexin, meteorin-like protein (METRNL), and oxyntomodulinwith explicit attention to the evidence supporting their metabolic roles, the reasons for historical underexploration, and the translational questions that remain unresolved