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Direct induction of uric acid degradation using enzymes such as the recombinant PEGylated uricase pegloticase is an alternative approach to hyperuricemia that targets excess body urate burden irrespective of its etiology and is particularly useful for severe tophaceous gout ( Difficult Gout and Hyperuricemia )

Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms

AGXT2 knockout mice exhibit increased asymmetric dimethylarginine and reduced NO and develop hypertension 139

An ideal scenario would involve the use of pro-senescence drugs with high efficacy in inducing senescence in a substantial proportion of cancer cells [60]

RX2016003), Wenzhou Science and Technology Bureau Foundation (grant No