GLP-1 agonists might protect the heart indirectly through their effects on weight, blood sugar, blood pressure, and inflammation
The multiple ways to affect the brain and modulate eating behaviour seem to explain the differences observed in body weight reductions between GLP-1RA compounds
26 Overall, the cardiovascular effects of GLP-1 RAs in HF can be realised through multiple pathways, including reducing visceral fat and EAT in obese HF patients
4 Mechanisms of hepatoprotection by GLP-1RAs as immune-metabolic modulators 4.1 Immunomodulatory mechanism of hepatic injuries by GLP-1RAs GLP-1RAs reduce inflammation, downregulate pro-inflammatory cytokines, and influence immune cell differentiation via the GLP-1 receptor, which alters macrophage polarization and inhibits fibrosis ( 4.1.1 GLP1-RAs attenuate the inflammation in MASLD by downregulating multiple inflammatory factors In animal models, GLP-1RAs have shown promising results in decreasing the expression of various inflammatory markers, including TLR2 and C-X3-C chemokine receptor 1 (CX3CR1), as well as reducing the expression of genes related to liver fibrosis and fat accumulation
What usually helps most is sustainable, realistic movement
