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Mechanism of action Semaglutide stimulates insulin secretion when blood glucose levels are elevated

(PubMed) Cipolla BG, Mandron E, Lefort JM, et al

Retrieved 21 December 2024

However, recruitment of mini-G s to Rab5-positive EEs was reduced to an even greater extent, which can be at least partly explained by the reduced rate of internalisation with this ligand, although differences in ability to maintain GLP-1R activation once internalised could also contribute