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The receptor is now recognized as a promising target for modulating neuroinflammation and microglia-mediated neuronal survival, particularly following the discovery of A 2A receptor upregulation in microglia from the prefrontal cortex of AD patients [483]

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The H-ESI source was operated in positive mode at spray voltage 3,500 or negative mode at spray voltage 2,500 with the following parameters: sheath gas 35 a.u., aux gas 7 a.u., sweep gas 0 a.u., ion transfer tube temperature 320 C, vaporizer temperature 275 C, mass range 70 to 1,000 m/z , full scan MS1 mass resolution of 120,000 FWHM, RF lens at 70% and standard AGC

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Am J Phys