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DOI: 10.1038/s41591-026-04416-4

Wu SX, Zhao XY, Yang YH, Zhou MQ, Zheng Y, Wu ZJ, Zou QY, Zhang TT, Du L

Early studies have compared its effects with single- and dual-agonist approaches to evaluate the magnitude and durability of metabolic effects

Updated analyses from the HEALEY ALS Platform Trial suggest a notable reduction in the risk of death in reviewed populations, alongside a favorable safety profile across more than 1,000 patient-years of exposure

Opioid analgesics are generally not recommended for long-term use due to risks of dependence and side effects, though tramadol may be considered for short-term rescue therapy only