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investigated the in vivo effects of intradiscal administration of osteogenic protein-1 (OP-1) and transforming growth factor-beta (TGF-) into the IVDs of rabbits
In a septic shock model induced by endotoxin (LPS) in rats, T4 administration significantly reduced lethality and downregulated inflammatory mediators, suggesting it could be a crucial component of the hosts natural response to sepsis and a potential therapeutic
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Vitamin D supplementation also improved ADHD symptoms [146,147], as observed in a study where 96 patients were given 50,000 IU/week 25-hydroxy-vitamin D3 for 6 weeks [145], as well as in a study involving 35 patients aged between 7 and 14 years who were administered 3000 IU/day 25-hydroxy-vitamin D3 over 12 weeks [146]
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