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254 Thalidomide is an immunomodulatory glutamate derivative that significantly reduces the protein expression levels of p-AKT and p-PI3K in intestinal epithelial cells and exerts anti-inflammatory effects by suppressing the activation of the PI3K/AKT pathway

This reduction in central fat contributes to a slimmer waistline and a lower risk of type 2 diabetes, insulin resistance, and cardiovascular disease