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In normoglycemic, non-obese rabbits , liraglutide significantly inhibited atherosclerosis progression, with meaningful reductions in percent atheroma volume, plaque macrophage content, cathepsin activity, and systemic CRP

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16,18 Early concerns about pancreatic safety arose from reports of pancreatitis in animal studies with the use of sitagliptin, clinical reports of humans treated with exenatide and the detection of preneoplastic pancreatic ductal lesions in animals treated with GLP-1 receptor agonists