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Notably, there was a significant decrease (7.5%) in AA in striatal tissues but a significant increase (18%) in SNcVTA tissues in mutants compared with controls (Fig

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Minimizing its use and instead using mirtazapine or sedative-hypnotics when appropriate would be another consideration

This makes them a convenient option for those with busy schedules or who do not want to take time off work or other activities

In addition, NRF2 activation was found crucial for the reprogramming of induced pluripotent stem cell (iPSC), which was known to be an inefficient process and required the metabolic shift from the oxidative phosphorylation to glycolysis as a major way to generate ATP