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Although initially activated to buffer metabolic stress, the PINK1-Parkin pathway becomes suppressed under chronic overload, such as prolonged palmitate exposure, resulting in dysfunctional mitochondria, heightened oxidative stress, and activation of the NLRP3 inflammasome

Unencapsulated si-PGC-1, LNP, and phosphate-buffered saline (PBS) were used as controls

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5 Immunohistochemistry of tumor necrosis factor- (TNF-) in the dorsal root ganglion (DRG) and spinal cord (SC) at phases (A) 1 and (B) 2 Graph (bottom) represents the number of immunostained cells in the DRG and SC (mean SD)

If you want a broader look at how glutathione fits into healthy aging, the Healthy Aging Supplements collection is a helpful place to browse