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To determine if the presence of low concentrations of tamoxifen causes a differential increase of ROS levels in CHO R C5 versus AuxB1, cells were exposed for 24 h to tamoxifen (1 M and 5 M) and intracellular ROS was quantified using 2',7'-dichlorodihydrofluorescein diacetate (H 2 DCFDA) dye [38]

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Conflict of interest JR-F declares that he has received honoraria for lectures for AstraZeneca, Boehringer Ingelheim, Novo Nordisk, Lilly, Sanofi, Novartis, Abbvie, Merck, and Bayer

Unlike single-hormone therapies, this combination approach often produces faster and more sustained results