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Suspected side effects should be reported to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk or through the Yellow Card app
TECOS, Trial Evaluating Cardiovascular Outcomes with Sitagliptin
gentle swirling is sufficient if mixing is required Minimise the number of times the vial is accessed, as repeated needle punctures increase contamination risk Label the vial clearly with the date and time of reconstitution, and with the sponsor-validated beyond-use date Follow all additional handling instructions specified in the IMP label or protocol These measures help to slow the degradation processes described above
Individual real-world studies (RWS) can, however, be non-representative
Some providers also check vitamin D, B12, and iron at baseline if nutritional deficiencies are suspected, though this is optional
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