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GLP-1 drugs are the next big thing, but this time, things appear to be different

Human DPP-4 is a 766-amino acid (aa) glycoprotein, consisting of several distinct regions: (1) A cytoplasmic domain (1 - 6 aa), (2) a transmembrane domain (7 - 28 aa), (3) a flexible stalk (29 - 39 aa), (4) a glycosylated region (101 - 350 aa), (5) cysteine-rich regions (55 - 100 aa and 351 - 497 aa), and (6) a catalytic region (506 - 766 aa) (63)

Other considerations include a small increased risk of lower limb amputation and bone fractures observed primarily with canagliflozin in certain trials

Imodium works by slowing down how quickly the gut moves, which allows the body to absorb more fluids and form firmer stools

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