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p53 exerts its functions in mitochondrial respiration, oxygen consumption, and antioxidant defense by promoting PARK2 expression, suggesting that activation of the p53PARK2 axis can limit cysteine deprivation-mediated ferroptosis

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Aging and skin cancer Aging is a tumor suppressor reaction, when the cancer stress stimulation, p53, and p16 tumor suppressor proteins control ways are established, so as to prevent stress cells in cell cycle progression and ultimately to the development of malignant tumor (154)