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A reasonable bar would be at least one phase 2 RCT in a clinically relevant population (cognitive impairment, mild Alzheimer disease, post-stroke recovery, or similar) showing clinical efficacy with acceptable safety

Both amounts restored Morris water maze performance relative to vehicle-treated APP/PS1 controls

With age, collagen density falls and existing collagen fragments which is why skin loses firmness and fine lines deepen

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For example, one study found that administration of DSIP significantly decreased sleep latency (how long it takes to fall asleep) and increased the amount of slow-wave sleep (delta wave sleep) in animal models