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Nevertheless, in the context of pathological stimuli such as hypoxia, microbial infection, or tumorigenesis, the levels of exRNA demonstrate a dosedependent increase, attaining concentrations 10to 100fold higher than the baseline [126]

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Therapy-induced senescent cells can re-enter the cell cycle to show aggressive proliferative and cancer stem-like properties, presenting a risk for recurrence and treatment resistance

Additionally, individual results may vary, and further research is needed to fully understand the long-term effects and optimal usage of these peptides