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Abstract Glucagon-like peptide 1 receptor agonists (GLP1RAs) are widely used for the treatment of type 2 diabetes mellitus (T2DM) and, at higher doses, obesity

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Arrhythmogenic right ventricular cardiomyopathy ARVC is a progressive cardiomyopathy caused by specific mutations, characterized by the loss of myocardial cells and their replacement with fibro-fatty tissue

Each cycle forces the peptide through conformational changes that can accelerate aggregation