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The Congressional Budget Office (CBO) has stated, "The developing market for [anti-obesity medications] could significantly affect health care spending and the federal budget." They contend that passage of the Treat and Reduce Obesity Act would increase costs for anti-obesity medications (i.e., because more people would use them) but reduce federal costs for other related health issues

Key findings include: Unprecedented HbA1c reductions ranging from 1.9% to 2.6% across different trials and populations SURPASS-1 (monotherapy): Up to 92% of participants achieved HbA1c less than 7%, with 52% reaching normoglycemia (HbA1c less than 5.7%) SURPASS-2 (versus semaglutide 1 mg): GLP2 demonstrated superior HbA1c and weight reduction at all doses compared to the leading GLP-1 receptor agonist SURPASS-3 (versus insulin degludec): Superior glycemic control when added to metformin with or without SGLT2 inhibitors SURPASS-4 (versus insulin glargine): Improved outcomes in patients with elevated cardiovascular risk Across all SURPASS trials, GLP2 showed consistent efficacy with low rates of clinically significant hypoglycemia (blood glucose less than 54 mg/dL)

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